Description

n-[4-(4-Fluorophenyl)-5-[(1E)-3-Hydroxy-1-Propen-1-Yl]-6-Isopropyl-2-Pyrimidinyl]-n-Methyl-Methanesulfonamide CAS NO 910867-08-2 is a high-purity, advanced pharmaceutical intermediate characterized by its specific pyrimidinyl and methanesulfonamide structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities and process chemistry.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of proprietary drug candidates, especially in oncology and anti-inflammatory research.
• API Development: Serves as a core structural component for constructing complex molecules with potential biological activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the efficient, large-scale production of target molecules.
• Biochemical Research: Potential use as a tool compound or inhibitor in enzymatic and receptor-binding assays.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke chemicals for clients.

Basic Information

Product Name	n-[4-(4-Fluorophenyl)-5-[(1E)-3-Hydroxy-1-Propen-1-Yl]-6-Isopropyl-2-Pyrimidinyl]-n-Methyl-Methanesulfonamide
CAS No.	910867-08-2
Molecular Formula	C20H24FN3O3S
Molecular Weight	405.49 g/mol
Synonyms	N-[4-(4-Fluorophenyl)-5-[(1E)-3-hydroxyprop-1-en-1-yl]-6-(propan-2-yl)pyrimidin-2-yl]-N-methylmethanesulfonamide; (1E)-3-Hydroxy-1-[4-(4-fluorophenyl)-2-[(methylsulfonyl)methylamino]-6-(1-methylethyl)-5-pyrimidinyl]-1-propen-1-ol; 910867-08-2; Methanesulfonamide, N-[4-(4-fluorophenyl)-5-[(1E)-3-hydroxy-1-propen-1-yl]-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements for preclinical and clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.