Description

4-tert-Butyl-3,5-Difluorophenol is a fluorinated phenolic compound of significant interest in advanced organic synthesis. This specialty chemical serves as a crucial building block for the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. Its unique structure, featuring both tert-butyl and fluorine substituents, makes it a valuable intermediate for researchers and manufacturers requiring precise molecular architecture. Key industries that utilize this compound include pharmaceutical R&D, agrochemical production, and material science.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the difluorophenol moiety enhances biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Polymer and Material Science: Incorporated as a monomer or additive to impart specific properties like thermal stability or hydrophobicity to advanced polymers.
• Liquid Crystal and Electronic Materials: Used in the synthesis of fluorinated components for liquid crystal displays (LCDs) and other electronic applications.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, etherifications, and other transformations to introduce the sterically hindered, fluorinated phenol group.

Basic Information

Product Name	4-tert-Butyl-3,5-Difluorophenol
CAS No.	910486-78-1
Molecular Formula	C10H12F2O
Molecular Weight	186.20 g/mol
Synonyms	3,5-Difluoro-4-tert-butylphenol; 4-(tert-Butyl)-3,5-difluorophenol; 2,6-Difluoro-4-tert-butylphenol; Phenol, 4-(1,1-dimethylethyl)-3,5-difluoro-; 4-tert-Butyl-3,5-difluorophenol; 3,5-Difluoro-4-(tert-butyl)phenol; 4-(tert-Butyl)-3,5-difluorophenol
EINECS	Contact for details

Quality Control

Our 4-tert-Butyl-3,5-Difluorophenol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to verify identity and purity. Certificates of Analysis (COA) detailing all test results are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, open flames, and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.