Description

(S)-4-(6-Chloro-4-Cyclopropyl-2-Oxo-3-(2,2,2-Trifluoroethyl)-1,2,3,4-Tetrahydroquinazolin-4-Yl)Benzonitrile is a high-purity, chiral pharmaceutical intermediate of significant synthetic value. Its complex molecular architecture, featuring a tetrahydroquinazolinone core with cyclopropyl and trifluoroethyl substituents, makes it a critical building block for advanced medicinal chemistry research. This compound is primarily sought after by R&D and process chemistry teams in the pharmaceutical and biotechnology sectors for the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Process Development: Serves as a critical starting material or advanced intermediate in scaling up synthetic routes for clinical trial material and commercial API manufacturing.
• Asymmetric Synthesis: Utilized in the synthesis of complex, stereochemically defined molecules due to its pre-installed (S)-configuration and functionalized core.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical industry.

Basic Information

Product Name	(S)-4-(6-Chloro-4-Cyclopropyl-2-Oxo-3-(2,2,2-Trifluoroethyl)-1,2,3,4-Tetrahydroquinazolin-4-Yl)Benzonitrile
CAS No.	910484-28-5
Molecular Formula	C22H17ClF3N3O
Molecular Weight	431.84 g/mol
Synonyms	(4S)-4-(4-Cyanophenyl)-6-chloro-4-cyclopropyl-3-(2,2,2-trifluoroethyl)-3,4-dihydroquinazolin-2(1H)-one; (S)-4-(6-Chloro-4-cyclopropyl-2-oxo-3-(2,2,2-trifluoroethyl)-1,2,3,4-tetrahydroquinazolin-4-yl)benzonitrile; 910484-28-5; UNII-6V8I8K165Y; SCHEMBL21806227; DTXSID60636690; BCP31033; AOB83707
EINECS	Contact for details

Quality Control

Our (S)-4-(6-Chloro-4-Cyclopropyl-2-Oxo-3-(2,2,2-Trifluoroethyl)-1,2,3,4-Tetrahydroquinazolin-4-Yl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.