Description

6-Chloro-4-Ethyl-4-(4-Fluorophenyl)-3,4-Dihydro-3-(2,2,2-Trifluoroethyl)-2(1H)-Quinazolinone is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of novel active pharmaceutical ingredients (APIs). This compound matters because it provides a critical, structurally complex building block for medicinal chemistry research and development, enabling the creation of new therapeutic agents. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on developing next-generation drugs, particularly in areas like oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, particularly for targeted therapies.
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and lead optimization.
• API Synthesis: Employed in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) for preclinical and clinical trials.
• Oncology Drug Development: Its quinazolinone core is of significant interest for developing kinase inhibitors and other anti-cancer agents.
• CNS Drug Discovery: Potential application in synthesizing compounds targeting neurological and psychiatric conditions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for exploratory organic synthesis and pharmacological studies.

Basic Information

Product Name	6-Chloro-4-Ethyl-4-(4-Fluorophenyl)-3,4-Dihydro-3-(2,2,2-Trifluoroethyl)-2(1H)-Quinazolinone
CAS No.	910483-02-2
Molecular Formula	C20H17ClF4N2O
Molecular Weight	412.81 g/mol
Synonyms	6-Chloro-4-ethyl-4-(4-fluorophenyl)-3-(2,2,2-trifluoroethyl)-3,4-dihydroquinazolin-2(1H)-one; 4-(4-Fluorophenyl)-4-ethyl-6-chloro-3-(2,2,2-trifluoroethyl)-3,4-dihydro-2(1H)-quinazolinone; 910483-02-2; Quinazolinone derivative, 6-chloro-4-ethyl-4-(4-fluorophenyl)-3-(2,2,2-trifluoroethyl)-3,4-dihydro-2(1H)-one; CAS 910483-02-2.
EINECS	Contact for details

Quality Control

Our 6-Chloro-4-Ethyl-4-(4-Fluorophenyl)-3,4-Dihydro-3-(2,2,2-Trifluoroethyl)-2(1H)-Quinazolinone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production adheres to cGMP (current Good Manufacturing Practice) standards where applicable, ensuring reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.