Description

4-[4-(Hydroxymethyl)Piperidin-1-Yl]Thieno[3,2-D]Pyrimidine is a high-value heterocyclic building block and pharmaceutical intermediate of significant interest in modern organic synthesis. This compound matters because its unique molecular architecture, combining piperidine, thienopyrimidine, and hydroxymethyl functionalities, makes it a versatile scaffold for constructing complex bioactive molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and development of new therapeutic agents, particularly within medicinal chemistry programs targeting kinase inhibition and other critical biological pathways.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel small-molecule drug candidates, especially for oncology and CNS targets.
• Kinase Inhibitor Scaffold: Used as a core structure in the design and development of potent and selective kinase inhibitors due to the thieno[3,2-d]pyrimidine moiety.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to optimize pharmacokinetic and pharmacodynamic properties of lead compounds.
• Chemical Biology Probe Development: Utilized to create tool compounds for investigating specific enzyme functions and cellular signaling pathways.
• Custom Synthesis Building Block: Provides a functionalized piperidine-thienopyrimidine hybrid for constructing bespoke chemical libraries for high-throughput screening.
• Agrochemical Research: Potential application as an intermediate in the development of new active ingredients for crop protection.

Basic Information

Item	Details
Product Name	4-[4-(Hydroxymethyl)Piperidin-1-Yl]Thieno[3,2-D]Pyrimidine
CAS No.	910037-26-2
Molecular Formula	C12H15N3OS
Molecular Weight	249.33 g/mol
Synonyms	4-(4-(Hydroxymethyl)piperidin-1-yl)thieno[3,2-d]pyrimidine; 1-(Thieno[3,2-d]pyrimidin-4-yl)-4-piperidinemethanol; 4-(4-Piperidinylmethyl)-1-piperidineethanol (related); Thieno[3,2-d]pyrimidine, 4-[4-(hydroxymethyl)-1-piperidinyl]-; 910037-26-2; Building Block 910037-26-2; CAS 910037-26-2
EINECS	Contact for details

Quality Control

Our 4-[4-(Hydroxymethyl)Piperidin-1-Yl]Thieno[3,2-D]Pyrimidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR, and MS for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.