Description

4,6-Dimethoxy-2-[(4-([6-(Trifluoromethyl)Pyridin-3-Yl]Methyl)Piperazin-1-Yl)Methyl]Pyrimidine is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. Its complex heterocyclic structure, featuring a trifluoromethylpyridine and a piperazine moiety, makes it a critical building block in modern medicinal chemistry. This compound is primarily sought after by pharmaceutical R&D and fine chemical synthesis teams for the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in therapeutic areas targeting the central nervous system, oncology, and infectious diseases.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of complex target molecules, leveraging its piperazine and pyrimidine functional groups.
• Biochemical Tool Compound: Employed in biochemical assays and as a reference standard for analytical method development and validation.
• Fine Chemical Production: Utilized in custom synthesis and contract manufacturing for producing specialized, high-value chemical entities.
• Agrochemical Research: Potential application as an intermediate in the development of new agrochemicals, given the bioactivity often associated with its structural motifs.

Basic Information

Product Name	4,6-Dimethoxy-2-[(4-([6-(Trifluoromethyl)Pyridin-3-Yl]Methyl)Piperazin-1-Yl)Methyl]Pyrimidine
CAS No.	909666-55-3
Molecular Formula	C18H22F3N5O2
Molecular Weight	397.40 g/mol
Synonyms	4,6-Dimethoxy-2-{[4-({6-[(trifluoromethyl)pyridin-3-yl]methyl}piperazin-1-yl)methyl]pyrimidine; 2-((4-((6-(Trifluoromethyl)pyridin-3-yl)methyl)piperazin-1-yl)methyl)-4,6-dimethoxypyrimidine; 4,6-Dimethoxy-2-[(4-{[6-(trifluoromethyl)pyridin-3-yl]methyl}piperazin-1-yl)methyl]pyrimidine; UNII-9B6T1I8V4C; 909666-55-3; 4,6-Dimethoxy-2-((4-((6-(trifluoromethyl)pyridin-3-yl)methyl)piperazin-1-yl)methyl)pyrimidine
EINECS	Contact for details

Quality Control

Our production of 4,6-Dimethoxy-2-[(4-([6-(Trifluoromethyl)Pyridin-3-Yl]Methyl)Piperazin-1-Yl)Methyl]Pyrimidine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity assay and spectroscopic identification (NMR, IR, MS). A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications. We support cGMP standards for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.