Description

2-Mercapto-L-Histidine S-Carboxylic Acid Ethyl Ester Dihydrochloride is a high-purity, protected derivative of the amino acid histidine, featuring a reactive thiol group. This compound is a critical building block in peptide synthesis and pharmaceutical research, offering precise control over molecular structure. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel bioactive peptides, enzyme inhibitors, and other advanced therapeutic agents.

Application

• Peptide Synthesis: Serves as a key protected intermediate for the solid-phase and solution-phase synthesis of histidine-containing peptides.
• Pharmaceutical Research: Used in the discovery and development of new drug candidates, particularly those targeting enzyme active sites or requiring metal coordination.
• Bioconjugation Chemistry: The reactive mercapto group enables site-specific labeling and conjugation with other biomolecules or polymers.
• Chemical Biology Probes: Acts as a precursor for synthesizing probes to study protein function, enzyme mechanisms, and cellular processes.
• Catalyst and Ligand Development: Utilized in the preparation of novel chiral ligands or catalysts for asymmetric synthesis.

Basic Information

Product Name	2-Mercapto-L-Histidine S-Carboxylic Acid Ethyl Ester Dihydrochloride
CAS No.	909272-14-6
Molecular Formula	C9H16Cl2N3O2S
Molecular Weight	301.21 g/mol
Synonyms	L-Histidine, 2-mercapto-, S-(carboxyethyl) ester, dihydrochloride; 2-Mercaptohistidine ethyl ester dihydrochloride; (2S)-2-Amino-3-(2-mercapto-1H-imidazol-4-yl)propanoic acid ethyl ester dihydrochloride; Histidine(2-Mercapto) ethyl ester 2HCl; 2-Thio-L-histidine ethyl ester dihydrochloride; Protected 2-mercaptohistidine; CAS 909272-14-6
EINECS	Contact for details

Quality Control

Our 2-Mercapto-L-Histidine S-Carboxylic Acid Ethyl Ester Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements for research and development applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.