Description

4-Chloro-2-Fluoro-3-Iodobenzaldehyde is a versatile halogenated benzaldehyde derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable precursor for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This high-purity intermediate is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogen functionalities into their target compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the halogen atoms contribute to biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalytic processes and material science applications.
• Functional Material Research: Employed in the synthesis of organic electronic materials, liquid crystals, and dyes due to its electron-withdrawing halogen substituents.
• Cross-Coupling Reactions: The iodine and chlorine atoms make it an excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form biaryl structures.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	4-Chloro-2-Fluoro-3-Iodobenzaldehyde
CAS No.	909186-22-7
Molecular Formula	C7H3ClFIO
Molecular Weight	299.45 g/mol
Synonyms	3-Iodo-4-chloro-2-fluorobenzaldehyde; 4-Chloro-2-fluoro-3-iodo-benzaldehyde; Benzaldehyde, 4-chloro-2-fluoro-3-iodo-; 2-Fluoro-4-chloro-3-iodobenzaldehyde; 3-Iodo-2-fluoro-4-chlorobenzaldehyde; 4-Chloro-2-fluoro-3-iodobenzenecarboxaldehyde
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluoro-3-Iodobenzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliable supply for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.