Description

Fmoc-Glu(Otbu)-Ser(Psi-Me,Mepro)-Oh CAS NO 909115-33-9 is a specialized, protected dipeptide building block used in solid-phase peptide synthesis (SPPS). This compound is critical for the efficient and high-fidelity assembly of complex peptides, particularly those containing challenging sequences or requiring specific side-chain protection. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of therapeutic peptides, peptide hormones, and biochemical tools. Its design ensures compatibility with standard Fmoc-chemistry protocols, offering reliability for advanced synthetic applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the sequential assembly of custom peptide sequences using Fmoc/t-Bu chemistry.
• Pharmaceutical Research & Development: For the synthesis of peptide-based drug candidates, including potential therapeutics for metabolic diseases, oncology, and neurology.
• Peptide Library Production: Enabling the creation of diverse peptide libraries for high-throughput screening in drug discovery programs.
• Bioconjugation and Probe Development: Serving as a precursor for synthesizing peptide tags, probes, or conjugates used in biochemical assays and diagnostic tools.
• Academic Research: Used in university and institutional labs for studying protein-protein interactions, enzyme substrates, and peptide structure-activity relationships.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of peptide active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Fmoc-Glu(Otbu)-Ser(Psi-Me,Mepro)-Oh
CAS No.	909115-33-9
Molecular Formula	C₃₄H₄₆N₂O₉
Molecular Weight	626.75 g/mol
Synonyms	Fmoc-Glu(OtBu)-Ser[Psi(Me,Mepro)]-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-tert-butyl-L-glutamyl-N-[(2S)-1-methyl-2-[(2-methylpropanoyl)amino]propyl]-L-serinamide; Fmoc-Glu(OtBu)-Ser(ψMe,Mepro)-OH; Fmoc-Glu(OtBu)-Ser[ψ(CH3NHCO-i-Pr)]-OH; Protected Fmoc-Glutamyl-Serine Dipeptide; Fmoc-Glu(OtBu)-Ser[Psi(Me,Mepro)]; Fmoc-L-Glu(OtBu)-L-Ser[Psi(Me,Mepro)]-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Glu(Otbu)-Ser(Psi-Me,Mepro)-Oh is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric integrity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee consistent quality and traceability for your research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.