Description

Angiopep-2 is a synthetic peptide designed to cross the blood-brain barrier (BBB) via receptor-mediated transcytosis. This compound is a critical tool in pharmaceutical research and development for creating targeted central nervous system (CNS) therapeutics. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel drug delivery systems for treating brain cancers, neurodegenerative diseases, and other CNS disorders.

Application

• Conjugation agent for enhancing the brain delivery of therapeutic antibodies and proteins.
• Key component in the development of targeted drug delivery systems for glioblastoma and other brain tumors.
• Research tool for studying receptor-mediated transport mechanisms across the blood-brain barrier.
• Building block for creating peptide-drug conjugates (PDCs) aimed at neurological targets.
• Used in preclinical models to evaluate the efficacy of novel CNS-targeting biopharmaceuticals.
• Facilitates the delivery of imaging agents for diagnostic applications in neurology.

Basic Information

Product Name	Angiopep-2
CAS No.	906480-05-5
Molecular Formula	C149H246N44O43S
Molecular Weight	3390.9 g/mol
Synonyms	Angiopep-2 Peptide; TFFYGGSRGKRNNFKTEEY; Angiopep 2; Angiopep2; BBB Shuttle Peptide Angiopep-2; LRP-1 Targeting Peptide
EINECS	Contact for details

Quality Control

Our Angiopep-2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and MS for identity confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.