Description

2-Bromo-1-(7-[(4-Methylphenyl)Sulfonyl]-7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Ethanone is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of targeted kinase inhibitors and other biologically active molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in oncology and inflammatory disease research.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potent kinase inhibitors and other small-molecule drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new therapeutic agents.
• Biochemical Tool Compound: Serves as a starting material or reference standard in biochemical assays to study enzyme inhibition and cellular signaling pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for clinical trial materials.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	2-Bromo-1-(7-[(4-Methylphenyl)Sulfonyl]-7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Ethanone
CAS No.	906092-48-6
Molecular Formula	C15H12BrN3O3S
Molecular Weight	394.24 g/mol
Synonyms	2-Bromo-1-[7-(4-methylphenyl)sulfonyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]ethanone; 2-Bromo-1-(7-(p-tolylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)ethan-1-one; 4-Acetyl-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl Bromide (incorrect but common); 906092-48-6; Pyrrolo[2,3-d]pyrimidine derivative; Kinase inhibitor intermediate; Tosyl-protected pyrrolopyrimidine bromo ketone.
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-(7-[(4-Methylphenyl)Sulfonyl]-7H-Pyrrolo[2,3-D]Pyrimidin-4-Yl)Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.