Description

1-(5-Bromo-4-Fluoro-2-Hydroxyphenyl)Ethanone is a high-purity, halogenated aromatic ketone building block of significant interest in advanced organic synthesis. Its unique structure, featuring bromo, fluoro, and phenolic hydroxyl substituents, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Serves as a building block for developing new herbicides and fungicides, leveraging the bioactivity of its halogenated phenolic structure.
• Material Science Research: Used in the development of specialty polymers and liquid crystals, where its halogen atoms and ketone group can modify material properties.
• Organic Light-Emitting Diode (OLED) Materials: Acts as an intermediate for creating electron-transport or host materials in OLED devices.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and protein interactions.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to form biaryl structures.

Basic Information

Product Name	1-(5-Bromo-4-Fluoro-2-Hydroxyphenyl)Ethanone
CAS No.	905454-90-2
Molecular Formula	C8H6BrFO2
Molecular Weight	233.04 g/mol
Synonyms	5'-Bromo-4'-fluoro-2'-hydroxyacetophenone; 1-(5-Bromo-4-fluoro-2-hydroxyphenyl)ethan-1-one; 2-Acetyl-4-bromo-5-fluorophenol; 5-Bromo-4-fluoro-2-hydroxyacetophenone; 4-Bromo-5-fluoro-2-hydroxyacetophenone; 2-Hydroxy-5-bromo-4-fluoroacetophenone; Ethanone, 1-(5-bromo-4-fluoro-2-hydroxyphenyl)-
EINECS	Contact for details

Quality Control

Our 1-(5-Bromo-4-Fluoro-2-Hydroxyphenyl)Ethanone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in GMP-aligned synthesis and research requiring high-fidelity intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.