Description

4-Bromo-3-Fluorophenyl Acetate is a high-purity fluorinated aromatic ester building block of significant interest in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by research chemists and process development scientists working on active pharmaceutical ingredients (APIs), liquid crystal materials, and specialty polymers.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides that incorporate halogenated aromatic motifs.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated compounds for liquid crystal displays (LCDs).
• Organic Light-Emitting Diodes (OLEDs): Employed in the synthesis of electron-transport or host materials for OLED devices.
• Polymer Chemistry: Acts as a monomer or modifier for creating specialty polymers with enhanced thermal or chemical resistance.
• Cross-Coupling Reactions: A valuable substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct biaryl systems.

Basic Information

Product Name	4-Bromo-3-Fluorophenyl Acetate
CAS No.	905454-89-9
Molecular Formula	C8H6BrFO2
Molecular Weight	233.04 g/mol
Synonyms	1-Acetoxy-4-bromo-3-fluorobenzene; 4-Bromo-3-fluorophenyl ethanoate; (4-Bromo-3-fluorophenyl) acetate; Acetic acid 4-bromo-3-fluorophenyl ester; 3-Fluoro-4-bromophenyl acetate; 905454-89-9; 4-Bromo-3-fluoro-1-phenol acetate
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-Fluorophenyl Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials such as strong bases and oxidizing agents. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.