Description

4-(3-Ethynylphenylamino)-7-Methoxyquinazolin-6-Ol is a high-purity, advanced pharmaceutical intermediate and research chemical. This compound is a key synthetic building block in the development of targeted kinase inhibitors, offering significant value for medicinal chemistry and drug discovery programs. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on oncology and signal transduction therapeutics.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel tyrosine kinase inhibitors (TKIs) and other targeted cancer therapies.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Biochemical Assay Development: Serves as a reference standard or probe compound in high-throughput screening (HTS) and enzymatic assays.
• Academic Research: Employed in university and institutional labs for investigating cellular signaling pathways and apoptosis mechanisms.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.

Basic Information

Product Name	4-(3-Ethynylphenylamino)-7-Methoxyquinazolin-6-Ol
CAS No.	905306-05-0
Molecular Formula	C18H13N3O2
Molecular Weight	303.32 g/mol
Synonyms	4-[(3-Ethynylphenyl)amino]-7-methoxy-6-quinazolinol; 6-Hydroxy-4-[(3-ethynylphenyl)amino]-7-methoxyquinazoline; 7-Methoxy-4-(3-ethynylphenylamino)quinazolin-6-ol; 905306-05-0; EGFR Inhibitor Intermediate; Quinazolin-6-ol derivative; Kinase inhibitor building block
EINECS	Contact for details

Quality Control

Our 4-(3-Ethynylphenylamino)-7-Methoxyquinazolin-6-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.