Description

tert-Butyl2-(Trifluoromethyl)-5H-Pyrrolo[3,4-D]Pyrimidine-6(7H)-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a fused pyrrolopyrimidine scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of targeted kinase inhibitors. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in creating novel therapeutic agents for oncology and inflammatory diseases.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potent and selective kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs.
• API Development: Serves as a precursor in the development of Active Pharmaceutical Ingredients (APIs) targeting specific enzymatic pathways.
• Chemical Biology Probes: Utilized in the creation of tool compounds for studying cellular signaling mechanisms.
• Custom Synthesis: Employed by CDMOs (Contract Development and Manufacturing Organizations) for client-specific molecule production.
• Preclinical Candidate Synthesis: Integral in the scale-up synthesis of compounds advancing to preclinical and clinical trial stages.

Basic Information

Product Name	tert-Butyl2-(Trifluoromethyl)-5H-Pyrrolo[3,4-D]Pyrimidine-6(7H)-Carboxylate
CAS No.	905274-03-5
Molecular Formula	C12H14F3N3O2
Molecular Weight	289.26 g/mol
Synonyms	tert-Butyl 2-(trifluoromethyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate; 6H-Pyrrolo[3,4-d]pyrimidine-6-carboxylic acid, 5,7-dihydro-2-(trifluoromethyl)-, 1,1-dimethylethyl ester; 2-(Trifluoromethyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylic acid tert-butyl ester; tert-Butyl 2-(trifluoromethyl)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidine-6-carboxylate; BOC-protected trifluoromethyl pyrrolopyrimidine; 905274-03-5
EINECS	Contact for details

Quality Control

Our production of tert-Butyl2-(Trifluoromethyl)-5H-Pyrrolo[3,4-D]Pyrimidine-6(7H)-Carboxylate adheres to stringent quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. All materials are fully characterized using advanced analytical techniques (NMR, HPLC-MS, IR). A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.