Description

2-(Methylamino)Pyrimidine-5-Boronic Acid Pinacol Ester is a high-value boronic ester derivative, a crucial protected intermediate in modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to synthesize novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides through palladium-catalyzed coupling reactions.
• Material Science Research: Serves as a precursor for creating functionalized organic molecules used in organic light-emitting diodes (OLEDs) and other advanced electronic materials.
• Chemical Biology & Probe Development: Employed in the construction of molecular probes and bioconjugates for studying biological pathways and target engagement.
• Library Synthesis for Drug Discovery: Facilitates the rapid generation of diverse compound libraries via parallel synthesis for high-throughput screening campaigns.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	2-(Methylamino)Pyrimidine-5-Boronic Acid Pinacol Ester
CAS No.	904326-88-1
Molecular Formula	C12H20BN3O2
Molecular Weight	249.12 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-methylpyrimidin-2-amine; 2-(Methylamino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2-Methylaminopyrimidine-5-boronic acid pinacol ester; 2-MAPB Pinacol Ester; 5-Borono-2-(methylamino)pyrimidine pinacol ester; N-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine
EINECS	Contact for details

Quality Control

Our 2-(Methylamino)Pyrimidine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure consistency and reliability. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and production needs across various standards, including cGMP for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.