Description

Na-Fmoc-Ne-Thioacetyl-L-Lysine is a sophisticated, orthogonally protected derivative of the essential amino acid L-lysine, designed for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring precise control over side-chain reactivity, particularly in the construction of complex peptides and bioconjugates. It is primarily utilized by pharmaceutical R&D teams, peptide synthesis service providers, and academic laboratories focused on developing novel therapeutic peptides, protein mimics, and chemical biology probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key building block for the controlled incorporation of lysine residues with a selectively deprotectable thioacetyl group on the Ne-amino side chain.
• Site-Specific Bioconjugation: Enables the precise attachment of payloads (e.g., fluorophores, drugs, polymers) to peptides via the reactive thioester functionality after selective deprotection.
• Native Chemical Ligation (NCL): Used in the synthesis of peptide thioesters, which are essential intermediates for coupling peptide fragments in protein total synthesis.
• Development of Peptide Therapeutics: Facilitates the creation of peptide-based drug candidates with modified pharmacokinetic properties or targeted delivery mechanisms.
• Chemical Biology Research: A valuable tool for probing protein-protein interactions and enzyme mechanisms through the introduction of stable, modifiable handles into peptide sequences.
• Material Science: Used in the synthesis of peptide-polymer hybrids and smart biomaterials where controlled functionalization is required.

Basic Information

Product Name	Na-Fmoc-Ne-Thioacetyl-L-Lysine
CAS No.	904314-07-4
Molecular Formula	C23H26N2O5S
Molecular Weight	442.53 g/mol
Synonyms	Fmoc-Lys(SAc)-OH; Nα-Fmoc-Nε-thioacetyl-L-lysine; Fmoc-Lys(Nε-thioacetyl)-OH; (2S)-6-(Acetylthio)-2-[(9H-fluoren-9-ylmethoxy)carbonylamino]hexanoic acid; Fmoc-Lys(S-acetyl)-OH; Nα-(9-Fluorenylmethoxycarbonyl)-Nε-(thioacetyl)-L-lysine; Fmoc-Lys(ThioAc)-OH; L-Lysine, N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N6-(acetylthio)-
EINECS	Contact for details

Quality Control

Our Na-Fmoc-Ne-Thioacetyl-L-Lysine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric integrity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee consistency and reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.