Description

tert-Butyl 3-Amino-2-Fluorobenzylcarbamate is a high-purity, fluorinated aromatic amine derivative protected with a Boc (tert-butoxycarbonyl) group. This compound serves as a critical pharmaceutical intermediate and versatile building block in advanced organic synthesis. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially those requiring a fluorinated aniline moiety.
• API (Active Pharmaceutical Ingredient) Development: Used in research and process chemistry for constructing candidate compounds in drug discovery pipelines.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with enhanced properties.
• Peptide Mimetics & PROTACs: The Boc-protected amine is valuable for introducing fluorinated benzyl groups into peptide backbones or linker systems for proteolysis-targeting chimeras.
• Material Science Research: Employed in the development of advanced polymers, liquid crystals, or organic electronic materials where fluorine substitution modulates properties.
• Cross-Coupling Reactions: The aromatic amine, after deprotection, can be used in Buchwald-Hartwig amination or as a directing group in metal-catalyzed functionalization.

Basic Information

Product Name	tert-Butyl 3-Amino-2-Fluorobenzylcarbamate
CAS No.	903556-52-5
Molecular Formula	C12H17FN2O2
Molecular Weight	240.28 g/mol
Synonyms	Carbamic acid, N-[(3-amino-2-fluorophenyl)methyl]-, 1,1-dimethylethyl ester; tert-Butyl N-[(3-amino-2-fluorophenyl)methyl]carbamate; Boc-3-Amino-2-fluorobenzylamine; N-Boc-3-Amino-2-fluorobenzylamine; 2-Fluoro-3-(Boc-aminomethyl)aniline; 3-Amino-2-fluorobenzylcarbamic acid tert-butyl ester; 903556-52-5; Boc-A2F-Bn
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Amino-2-Fluorobenzylcarbamate is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request. We support cGMP standards for pharmaceutical applications and can accommodate custom purity requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.