Description

n-Cbz-3-Bromo-2-Fluoroaniline is a high-purity, protected aniline derivative serving as a critical building block in advanced organic synthesis. This compound is essential for the efficient construction of complex molecules, particularly in pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing halogenated aromatic systems.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs targeting various diseases.
• Agrochemical Synthesis: Serves as a building block for developing novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Peptide Mimetics & PROTACs: The Cbz-protected amine is a versatile handle for constructing peptide-like molecules and proteolysis-targeting chimeras (PROTACs).
• Material Science: Can be incorporated into the synthesis of specialty polymers and advanced organic materials with specific electronic or structural properties.
• Cross-Coupling Reactions: The bromo substituent makes it a valuable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl structures.

Basic Information

Product Name	n-Cbz-3-Bromo-2-Fluoroaniline
CAS No.	903556-49-0
Molecular Formula	C₁₄H₁₁BrFNO₂
Molecular Weight	324.15 g/mol
Synonyms	Carbobenzyloxy-3-bromo-2-fluoroaniline; N-[(Benzyloxy)carbonyl]-3-bromo-2-fluoroaniline; 3-Bromo-2-fluoro-N-(phenylmethoxy)carbonylaniline; 1-[(Benzyloxy)carbonylamino]-3-bromo-2-fluorobenzene; N-Cbz-3-Br-2-F-aniline; Benzyl (3-bromo-2-fluorophenyl)carbamate; Z-3-Bromo-2-fluoroaniline
EINECS	Contact for details

Quality Control

Our n-Cbz-3-Bromo-2-Fluoroaniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.