Description

Ethyl 4-Methyl-2-(4-Phenylpiperazin-1-Yl)-Pyrimidine-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate with a distinct pyrimidine-piperazine core structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily sought by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the research and synthesis of potential drug candidates, especially for central nervous system (CNS) and receptor-targeted therapies.
• Medicinal Chemistry Research: Used as a versatile scaffold in structure-activity relationship (SAR) studies and lead optimization programs within R&D laboratories.
• API Process Development: Employed in the scale-up and process chemistry stages for developing robust and efficient synthetic routes to new chemical entities.
• Biochemical Research: Utilized in biochemical assays and as a tool compound for studying specific biological pathways and enzyme interactions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and pilot-scale production projects.

Basic Information

Product Name	Ethyl 4-Methyl-2-(4-Phenylpiperazin-1-Yl)-Pyrimidine-5-Carboxylate
CAS No.	903446-60-6
Molecular Formula	C18H22N4O2
Molecular Weight	326.40 g/mol
Synonyms	Ethyl 4-methyl-2-(4-phenyl-1-piperazinyl)-5-pyrimidinecarboxylate; 2-(4-Phenylpiperazin-1-yl)-4-methylpyrimidine-5-carboxylic acid ethyl ester; 903446-60-6; UNII-9J8I3V55QO; 9J8I3V55QO; SCHEMBL218062; AKOS025147213; ZINC000004098756
EINECS	Contact for details

Quality Control

Our Ethyl 4-Methyl-2-(4-Phenylpiperazin-1-Yl)-Pyrimidine-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.