Description

Ethyl 2-(3,4-Dihydroisoquinolin-2(1H)-yl)-4-methylpyrimidine-5-carboxylate is a high-purity, advanced pharmaceutical intermediate of significant interest in modern organic synthesis. This compound matters for its role as a key building block in the research and development of novel bioactive molecules, particularly in the central nervous system (CNS) and oncology therapeutic areas. Pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers need it for constructing complex heterocyclic scaffolds. Its defined structure enables precise molecular modifications critical for drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of potential drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Chemical Biology Probes: Employed in the development of tool compounds for studying enzyme function and biological target engagement.
• Academic Research: Utilized in universities and research institutes for methodological development in heterocyclic and alkaloid chemistry.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up campaigns.

Basic Information

Item	Details
Product Name	Ethyl 2-(3,4-Dihydroisoquinolin-2(1H)-yl)-4-methylpyrimidine-5-carboxylate
CAS No.	903446-37-7
Molecular Formula	C17H19N3O2
Molecular Weight	297.35 g/mol
Synonyms	Ethyl 2-(1,2,3,4-tetrahydroisoquinolin-2-yl)-4-methylpyrimidine-5-carboxylate; 5-Pyrimidinecarboxylic acid, 2-(3,4-dihydro-2(1H)-isoquinolinyl)-4-methyl-, ethyl ester; 903446-37-7; Ethyl 4-methyl-2-(1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine-5-carboxylate; 2-(3,4-Dihydroisoquinolin-2(1H)-yl)-4-methylpyrimidine-5-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-(3,4-Dihydroisoquinolin-2(1H)-yl)-4-methylpyrimidine-5-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP standards where required for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.