Description

5-Bromo-2,4-difluoropyrimidine is a high-purity halogenated pyrimidine building block essential for advanced organic synthesis. This compound is valued for its dual halogen functionality, which facilitates selective cross-coupling reactions and nucleophilic substitutions, enabling the rapid construction of complex heterocyclic scaffolds. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of antiviral, anticancer, and kinase inhibitor drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides.
• Material Science: Serves as a precursor for functionalized ligands and monomers in specialty polymers.
• Chemical Research: Employed in medicinal chemistry and process R&D for structure-activity relationship (SAR) studies.
• Cross-Coupling Reactions: Acts as a versatile substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions.
• Nucleophilic Aromatic Substitution: The fluorine atoms provide excellent leaving groups for displacement with various nucleophiles.

Basic Information

Product Name	5-Bromo-2,4-Difluoropyrimidine
CAS No.	903131-29-3
Molecular Formula	C4HBrF2N2
Molecular Weight	194.96 g/mol
Synonyms	2,4-Difluoro-5-bromopyrimidine; 5-Bromo-2,4-difluoropyrimidine; Pyrimidine, 5-bromo-2,4-difluoro-; 903131-29-3; 5-Br-2,4-F2-Pyrimidine
EINECS	Contact for details

Quality Control

Our 5-Bromo-2,4-difluoropyrimidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.