Description

(9H-Fluoren-9-Yl)Methyl 2,4-Dichloro-7,8-Dihydropyrido[4,3-D]Pyrimidine-6(5H)-Carboxylate CAS NO 903130-16-5 is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of critical importance in modern medicinal chemistry, serving as a key building block for the synthesis of novel, targeted therapeutic agents. It is primarily required by research institutions and pharmaceutical companies engaged in the development of kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of investigational new drugs (INDs), particularly those targeting specific enzymatic pathways.
• Kinase Inhibitor Development: Serves as a core scaffold for constructing potent and selective kinase inhibitors, a major class of oncology and anti-inflammatory therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize drug candidate potency, selectivity, and pharmacokinetic properties.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the efficient, large-scale production of active pharmaceutical ingredients (APIs).
• Biochemical Probe Synthesis: Facilitates the creation of chemical tools for studying biological mechanisms and validating new drug targets in vitro and in vivo.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific novel chemical entities.

Basic Information

Product Name	(9H-Fluoren-9-Yl)Methyl 2,4-Dichloro-7,8-Dihydropyrido[4,3-D]Pyrimidine-6(5H)-Carboxylate
CAS No.	903130-16-5
Molecular Formula	C23H19Cl2N3O2
Molecular Weight	440.32 g/mol
Synonyms	Fmoc-2,4-Dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-6-carboxylate; 6-(((9H-Fluoren-9-yl)methoxy)carbonyl)-2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine; 2,4-Dichloro-6-((((9H-fluoren-9-yl)methoxy)carbonyl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine; N-Fmoc-2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-6-carboxylic acid; (9-Fluorenylmethyl) 2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-6-carboxylate
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems and undergoes comprehensive analytical characterization. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry to confirm identity, purity, and conformity to client specifications. Our quality protocols are designed to support cGMP-compliant pharmaceutical development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. For long-term storage, consider storage under inert atmosphere (argon or nitrogen) to maintain optimal stability. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.