Description

Ditert-Butyl [6-[[5-Fluoro-2-(3,4,5-Trimethoxyanilino)Pyrimidin-4-Yl]Amino]-2,2-Dimethyl-3-Oxo-Pyrido[3,2-B][1,4]Oxazin-4-Yl]Methyl Phosphate is a sophisticated, high-purity chemical intermediate designed for advanced pharmaceutical research and development. This compound is critical for medicinal chemists exploring novel kinase inhibitors and targeted cancer therapies due to its specific molecular architecture. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic research institutions focused on oncology and signal transduction pathways.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of investigational kinase inhibitor drugs.
• Oncology Research: Used in the development of targeted therapeutic agents for cancer treatment.
• Biochemical Assay Development: Serves as a reference standard or active component in high-throughput screening (HTS) and enzyme inhibition studies.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Preclinical Development: Supports the synthesis of compounds for pharmacokinetic, pharmacodynamic, and toxicology evaluations.
• Academic Research: Facilitates fundamental research in cell signaling pathways and drug discovery methodologies.

Basic Information

Product Name	Ditert-Butyl [6-[[5-Fluoro-2-(3,4,5-Trimethoxyanilino)Pyrimidin-4-Yl]Amino]-2,2-Dimethyl-3-Oxo-Pyrido[3,2-B][1,4]Oxazin-4-Yl]Methyl Phosphate
CAS No.	901119-38-8
Molecular Formula	C33H42FN6O8P
Molecular Weight	700.70 g/mol
Synonyms	Di-tert-butyl (6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-3,4-dihydropyrido[3,2-b][1,4]oxazin-4-yl)methyl phosphate; 901119-38-8; UNII-0XH6QN5Q1F; 0XH6QN5Q1F; CHEMBL3186661; BDBM50157873; AKOS025147024; CS-0446043.
EINECS	Contact for details

Quality Control

Our production of Ditert-Butyl [6-[[5-Fluoro-2-(3,4,5-Trimethoxyanilino)Pyrimidin-4-Yl]Amino]-2,2-Dimethyl-3-Oxo-Pyrido[3,2-B][1,4]Oxazin-4-Yl]Methyl Phosphate adheres to stringent quality protocols suitable for research and development applications. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurities is provided with every shipment to ensure traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.