Description

6Alpha-Deoxy-6Alpha-Azido-4Alpha-Deoxy-4Alpha-(Thymin-1-Yl)-2,3Alpha:2Alpha,5Alpha-Dianhydro-L-Altrofuranose Dimethyl Acetal is a sophisticated nucleoside analogue building block of significant interest in advanced pharmaceutical research and development. This compound matters as a key synthetic intermediate for the creation of novel antiviral and anticancer agents, particularly in the field of modified nucleosides and oligonucleotides. It is primarily needed by R&D chemists and process development scientists in pharmaceutical, biotechnology, and fine chemical sectors focused on next-generation therapeutics.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel nucleoside-based antiviral drugs.
• Anticancer Agent Research: Used in the development of prodrugs and targeted therapies that interfere with DNA synthesis in cancer cells.
• Oligonucleotide Synthesis: Serves as a modified monomer for constructing antisense oligonucleotides and siRNA strands with enhanced stability and specificity.
• Medicinal Chemistry: A versatile scaffold for structure-activity relationship (SAR) studies to optimize pharmacokinetic and pharmacodynamic properties.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).
• Biochemical Probes: Utilized in the creation of labeled nucleotides for studying enzymatic mechanisms and nucleic acid interactions.

Basic Information

Product Name	6Alpha-Deoxy-6Alpha-Azido-4Alpha-Deoxy-4Alpha-(Thymin-1-Yl)-2,3Alpha:2Alpha,5Alpha-Dianhydro-L-Altrofuranose Dimethyl Acetal
CAS No.	900513-67-9
Molecular Formula	C14H18N6O6
Molecular Weight	366.33 g/mol
Synonyms	1-[(2R,3S,4R,5R)-5-Azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione dimethyl acetal; 6-Azido-6-deoxy-4-(thymin-1-yl)-2,3:2,5-dianhydro-L-altrofuranose dimethyl acetal; 4-(Thymin-1-yl)-2,3:2,5-dianhydro-6-azido-6-deoxy-L-altrofuranose dimethyl acetal; Modified L-Nucleoside Intermediate; Dianhydro-altrofuranose-thymine azido derivative
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality control protocols suitable for research and development use. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and Mass Spectrometry to ensure structural identity and purity. While not compendial (USP/EP), our production adheres to internal quality standards designed for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccant packs or storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.