Description

Vorapaxar is a potent and selective antagonist of protease-activated receptor-1 (PAR-1), which plays a critical role in thrombin-mediated platelet activation. This targeted mechanism makes it a valuable active pharmaceutical ingredient (API) for advanced cardiovascular research and development. It is primarily utilized by pharmaceutical companies and research institutions focused on developing novel antiplatelet therapies to reduce the risk of thrombotic events, such as heart attack and stroke, in high-risk patient populations.

Application

• Pharmaceutical API: Serves as the core active ingredient in the formulation of finished antiplatelet medications.
• Cardiovascular Research: Used in preclinical and clinical studies to investigate the inhibition of thrombin-induced platelet aggregation.
• Drug Development: A key compound for developing new therapeutic agents aimed at preventing arterial thrombosis.
• Biochemical Assays: Employed as a reference standard in pharmacological and biochemical testing to study PAR-1 receptor activity.
• Mechanism of Action Studies: Utilized in academic and industrial labs to elucidate pathways of platelet activation and thrombus formation.

Basic Information

Product Name	Vorapaxar
CAS No.	900161-12-8
Molecular Formula	C29H33FN2O4
Molecular Weight	492.58 g/mol
Synonyms	SCH 530348; Vorapaxar sulfate; (1R,3aR,4aR,9bS)-6-(3-Fluorophenyl)-1-(methoxymethyl)-2,3,3a,4a,5,9b-hexahydro-1H-cyclopenta[c]quinolin-4-yl N-[(1S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-methylpropyl]carbamate; Zontivity (brand name); PAR-1 antagonist
EINECS	Contact for details

Quality Control

Our Vorapaxar is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) are provided, detailing parameters such as identity, purity, and impurity profiles as per in-house specifications. We adhere to cGMP principles where applicable to ensure supply reliability and batch-to-batch consistency for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.