Description

Cyclo(Glycyl-Prolyl-Psi(Ch2S)-Glycyl-Phenylalanyl-Prolyl) is a synthetic cyclic peptide containing a thioether bridge, representing a constrained structural analog of bioactive sequences. This compound is significant for its role in advanced pharmaceutical research, particularly in the study of enzyme inhibition, receptor binding, and peptide stability. It is primarily needed by research institutions and pharmaceutical companies engaged in drug discovery, proteomics, and the development of novel therapeutic agents targeting various disease pathways.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the discovery of new drugs, particularly for metabolic and neurological disorders.
• Protease Inhibition Studies: Used as a model substrate or inhibitor to study the mechanism and kinetics of specific proteolytic enzymes.
• Peptide Mimetics Development: Acts as a scaffold for designing and synthesizing more stable, bioavailable peptide mimetics with enhanced pharmacological properties.
• Biochemical Assays: Employed in high-throughput screening (HTS) assays to identify and characterize potential lead compounds.
• Academic Research: Utilized in university and institutional labs for fundamental studies in peptide chemistry, conformational analysis, and structure-activity relationships (SAR).
• Reference Standard: Provides a high-purity benchmark for quality control and analytical method development in peptide synthesis and characterization.

Basic Information

Product Name	Cyclo(Glycyl-Prolyl-Psi(Ch2S)-Glycyl-Phenylalanyl-Prolyl)
CAS No.	99781-72-3
Molecular Formula	C29H38N6O5S
Molecular Weight	582.71 g/mol
Synonyms	Cyclo(Gly-Pro-Psi(CH2S)-Gly-Phe-Pro); Cyclo[Gly-Pro-ψ(CH2S)-Gly-Phe-Pro]; Thioether-bridged cyclic hexapeptide; c[GPψ(CH2S)GFP]; Cyclic GPψ(CH2S)GFP; Cyclo(Gly-Pro-(Cys-S-CH2)-Gly-Phe-Pro) (disulfide bridge analog); CAS 99781-72-3
EINECS	Contact for details

Quality Control

Our Cyclo(Glycyl-Prolyl-Psi(Ch2S)-Glycyl-Phenylalanyl-Prolyl) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, MS for identity confirmation, and NMR for structural verification, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.