Description

5-Nitro-4-Hydroxyquinazoline is a high-purity, functionalized quinazoline derivative of significant interest in advanced organic synthesis. This compound serves as a critical synthetic intermediate and a versatile scaffold for the development of novel pharmacologically active molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for the discovery of kinase inhibitors and other targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Chemical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Organic Synthesis: Employed in various organic transformations to introduce the nitro-hydroxy-quinazoline moiety into more complex molecular architectures.
• Biochemical Tool Compound: Utilized in biochemical assays to study enzyme function and inhibition mechanisms.
• Agrochemical Research: Investigated as a precursor for developing new active ingredients in crop protection science.

Basic Information

Product Name	5-Nitro-4-Hydroxyquinazoline
CAS No.	99768-67-9
Molecular Formula	C8H5N3O3
Molecular Weight	191.15 g/mol
Synonyms	4-Hydroxy-5-nitroquinazoline; 5-Nitroquinazolin-4-ol; 5-Nitro-4(3H)-quinazolinone; 4-Hydroxy-5-nitro-1,3-diazanaphthalene; Quinazoline, 4-hydroxy-5-nitro-; 99768-67-9 (CAS)
EINECS	Contact for details

Quality Control

Our 5-Nitro-4-Hydroxyquinazoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, prolonged exposure to light and air should be minimized. For long-term storage, consider keeping the container under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.