Description

H-Leu-Ser-p-Nitro-Phe-Nle-Ala-Leu-Ome Tfa is a synthetic, protected peptide sequence of significant interest in advanced biochemical research and pharmaceutical development. This compound serves as a critical intermediate or reference standard in the study of peptide structure-activity relationships and enzyme-substrate interactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in protease inhibitor design, peptide hormone analog development, and high-throughput screening assays.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly for investigating serine or cysteine protease activity and kinetics.
• Pharmaceutical R&D: Serves as a key building block or intermediate in the synthesis of novel therapeutic peptide candidates and analogs.
• Proteomics: Employed as a reference standard or calibration compound in mass spectrometry and chromatographic analysis of complex peptide mixtures.
• Drug Discovery Platforms: Integrated into screening libraries for identifying and optimizing lead compounds targeting specific biological pathways.
• Academic Research: Utilized in university laboratories for fundamental studies on peptide stability, folding, and receptor binding mechanisms.

Basic Information

Product Name	H-Leu-Ser-p-Nitro-Phe-Nle-Ala-Leu-Ome Tfa
CAS No.	99764-63-3
Molecular Formula	C41H59N7O11 • C2HF3O2
Molecular Weight	~ 915.95 g/mol (as TFA salt)
Synonyms	H-Leu-Ser-pNO2-Phe-Nle-Ala-Leu-OMe • TFA; Leu-Ser-p-Nitro-Phe-Nle-Ala-Leu-OMe trifluoroacetate; p-Nitro-Phe-containing heptapeptide; N-Acetyl-Leu-Ser-p-Nitro-Phe-Nle-Ala-Leu-OMe (TFA salt); Protease Substrate Analog; Heptapeptide TFA Salt CAS 99764-63-3; L-Leucyl-L-seryl-N-[N-[N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-hydroxy-2-oxopropyl]amino]-4-(4-nitrophenyl)-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]norleucyl]alanyl]-L-leucine methyl ester trifluoroacetate
EINECS	Contact for details

Quality Control

Our peptide products are manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, MS, and NMR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.