Description

1-Ethyl-4-Oxo-6,8-Difluoro-7-Piperazino-1,4-Dihydroquinoline-3-Carboxylic Acid is a high-purity advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of modern fluoroquinolone antibiotics, enabling the development of potent antimicrobial agents. It is primarily required by pharmaceutical manufacturers and R&D organizations focused on active pharmaceutical ingredient (API) production and novel drug development.

Application

• Key Intermediate for Fluoroquinolone Antibiotics: A vital precursor in the synthesis of advanced-generation antibacterial agents.
• Pharmaceutical R&D: Used in research laboratories for developing new antimicrobial compounds and studying structure-activity relationships (SAR).
• Active Pharmaceutical Ingredient (API) Manufacturing: Incorporated into the production process of final drug substances for commercial pharmaceutical products.
• Chemical Synthesis Reference Standard: Serves as a high-purity standard for analytical method development and quality control in pharmaceutical analysis.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes and scaling production from laboratory to pilot plant and commercial manufacturing.

Basic Information

Product Name	1-Ethyl-4-Oxo-6,8-Difluoro-7-Piperazino-1,4-Dihydroquinoline-3-Carboxylic Acid
CAS No.	99726-76-8
Molecular Formula	C16H17F2N3O3
Molecular Weight	337.32 g/mol
Synonyms	1-Ethyl-6,8-difluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid; 7-Piperazino-1-ethyl-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid; 1-Ethyl-6,8-difluoro-7-piperazin-1-yl-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid; Difloxacin Intermediate; DIFLOXACIN Impurity; 99726-76-8; 1-Ethyl-6,8-difluoro-7-(piperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid
EINECS	Contact for details

Quality Control

Our 1-Ethyl-4-Oxo-6,8-Difluoro-7-Piperazino-1,4-Dihydroquinoline-3-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure it meets the high-purity standards required for pharmaceutical synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.