Description

Tos-Gly-Pro-Arg-Anba-Ipa CAS NO 99700-50-2 is a specialized synthetic peptide derivative, primarily utilized as a chromogenic substrate for the detection and quantification of thrombin and related serine proteases. This compound matters for its high specificity and sensitivity in biochemical assays, enabling critical research and diagnostic applications in hemostasis and thrombosis studies. It is essential for pharmaceutical R&D laboratories, diagnostic kit manufacturers, and academic institutions focused on cardiovascular disease, coagulation pathways, and enzyme kinetics.

Application

• Primary substrate in chromogenic assays for measuring thrombin activity and inhibition.
• Critical reagent in the development and quality control of diagnostic kits for blood coagulation disorders.
• Used in biochemical research to study serine protease kinetics and inhibitor screening.
• Tool compound in pharmaceutical development for anticoagulant drug discovery and efficacy testing.
• Applied in clinical laboratories for specialized coagulation factor analysis.
• Utilized in enzymology studies to understand substrate specificity and enzymatic mechanisms.

Basic Information

Product Name	Tos-Gly-Pro-Arg-Anba-Ipa
CAS No.	99700-50-2
Molecular Formula	C38H52N10O9S
Molecular Weight	824.96 g/mol
Synonyms	H-D-Phe-Pip-Arg-pNA; Tosyl-Glycyl-Prolyl-Arginyl-4-Amino-3-Nitrobenzoic Acid Isopropyl Amide; Chromogenic Substrate for Thrombin; Thrombin Substrate I (Chromogenic); Bz-Phe-Val-Arg-pNA (related analog); S-2238 (related commercial name); H-D-Phe-Pip-Arg-p-nitroanilide; Tos-Gly-Pro-Arg-ANBA-IPA
EINECS	Contact for details

Quality Control

Our Tos-Gly-Pro-Arg-Anba-Ipa is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, typically exceeding 95% (HPLC). Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for research-grade biochemicals, ensuring reliability for your critical assays and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.