Description

3,4,5-Trifluorophenol is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its trifluoromethyl-substituted phenolic structure, which imparts unique electronic and steric properties critical for modulating the biological activity and physicochemical characteristics of target molecules. It is primarily utilized by R&D and production teams in the pharmaceutical, agrochemical, and specialty materials industries for developing new active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and manufacture of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance metabolic stability and bioavailability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance displays.
• Polymer Modification: Employed to introduce fluorine groups into polymer backbones, improving chemical resistance, thermal stability, and surface properties.
• Organic Electronics: Acts as a building block for electron-transport materials and emissive layers in OLEDs and other electronic devices.
• Chemical Research: A versatile reagent for Suzuki, Sonogashira, and other cross-coupling reactions in medicinal and process chemistry.

Basic Information

Product Name	3,4,5-Trifluorophenol
CAS No.	99627-05-1
Molecular Formula	C6H3F3O
Molecular Weight	148.08 g/mol
Synonyms	3,4,5-Trifluorophenol; 1-Hydroxy-3,4,5-trifluorobenzene; Phenol, 3,4,5-trifluoro-; 3,4,5-Trifluoro-1-hydroxybenzene; 3,4,5-Trifluorobenzenol; TFP
EINECS	Contact for details

Quality Control

Our 3,4,5-Trifluorophenol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. We provide full traceability and detailed Certificates of Analysis (COA) for all shipments. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates and ISO standards for industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in the original packaging or amber glass until use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	45 - 50 °C
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.