Description

Siguazodan is a selective phosphodiesterase III (PDE III) inhibitor, a high-purity chemical compound of significant interest in pharmaceutical research and development. Its primary value lies in its potent inotropic and vasodilatory properties, making it a key candidate for cardiovascular studies. This product is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on developing novel therapeutic agents for heart failure and related conditions. Siguazodan CAS NO 99591-83-0 is supplied under stringent quality controls to ensure reliability for critical R&D and scale-up processes.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in drug manufacturing.
• Cardiovascular Research: Serves as a critical pharmacological tool in preclinical studies investigating inotropic agents and vasodilators for treating congestive heart failure.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) and enzymatic assays to study PDE III inhibition and its downstream cellular effects.
• Active Pharmaceutical Ingredient (API) Intermediate: Utilized in the synthetic pathway for developing novel PDE III inhibitor-based drug candidates.
• Academic and Institutional Research: Supports basic science research in pharmacology, molecular biology, and medicinal chemistry at universities and research institutes.

Basic Information

Product Name	Siguazodan
CAS No.	99591-83-0
Molecular Formula	C20H19N5O2S
Molecular Weight	393.46 g/mol
Synonyms	1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid; 6-Fluoro-1-cyclopropyl-7-piperazin-1-yl-4-quinolone-3-carboxylic acid; PD 117,596; PD-117596; PD117596; (RS)-Siguazodan; (±)-Siguazodan
EINECS	Contact for details

Quality Control

Every batch of Siguazodan is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical development. Certificates of Analysis (COA) are available upon request, providing detailed results for identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.