Description

Neuropeptide Y (Human, Rat) CAS NO 99575-89-0 is a 36-amino acid peptide neurotransmitter belonging to the pancreatic polypeptide family, widely recognized for its potent orexigenic (appetite-stimulating) and vasoconstrictive effects. This high-purity research-grade peptide is essential for advancing studies in neurobiology, metabolic regulation, and cardiovascular physiology. It is a critical reagent for pharmaceutical R&D, academic research, and diagnostic assay development targeting obesity, anxiety, and hypertension pathways.

Application

• Neuroscience Research: Investigation of central nervous system functions, including feeding behavior, anxiety, stress response, and circadian rhythms.
• Metabolic Disorder Studies: Target validation and mechanistic studies for obesity, diabetes, and metabolic syndrome drug discovery programs.
• Cardiovascular Research: Exploration of its role in blood pressure regulation, vascular tone, and heart function.
• Immunology Research: Study of interactions between the nervous and immune systems.
• Assay Development: Used as a standard or calibrator in ELISA, RIA, and other immunoassays for quantitative analysis.
• Receptor Binding Studies: Essential ligand for characterizing and mapping Y1, Y2, Y4, Y5, and y6 receptor subtypes.
• Cell Signaling Pathways: Tool for studying intracellular signal transduction mechanisms mediated by NPY receptors.

Basic Information

Item	Details
Product Name	Neuropeptide Y (Human, Rat)
CAS No.	99575-89-0
Molecular Formula	C190H287N55O57S2
Molecular Weight	4251.8 g/mol
Synonyms	Neuropeptide Y; NPY; Neuropeptide Tyrosine; Pancreatic Polypeptide Y; hNPY; rNPY; Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Leu-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2 (Human sequence); Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2 (Rat sequence)
EINECS	Contact for details

Quality Control

Our Neuropeptide Y (Human, Rat) is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot is subjected to comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Composition	Within ±10% of theoretical values
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	≤ 10.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.