Description

Gramicidin A, 7-Alanine- is a defined analog of the naturally occurring antibiotic peptide gramicidin A, where the tryptophan residue at position 7 is replaced by alanine. This specific modification is crucial for research into the structure-activity relationships of ion channel formation and antimicrobial mechanisms. It is an essential tool compound for pharmaceutical R&D, biochemistry, and microbiology laboratories studying membrane-active peptides, antibiotic resistance, and novel therapeutic agents.

Application

• Biochemical Research: Used as a model compound to study the formation and function of monovalent cation channels in lipid bilayers and cell membranes.
• Antimicrobial Studies: Serves as a reference standard in research focused on the mechanisms of action, resistance, and efficacy of peptide-based antibiotics.
• Structure-Activity Relationship (SAR) Analysis: The specific alanine substitution at position 7 makes it invaluable for investigating how amino acid sequence and hydrophobicity affect ion channel stability and selectivity.
• Pharmaceutical Development: Acts as a key intermediate or reference material in the development and screening of novel antimicrobial peptides and peptidomimetics.
• Membrane Biophysics: Employed in experiments to understand peptide-lipid interactions, membrane permeability, and the thermodynamics of channel formation.

Basic Information

Product Name	Gramicidin A, 7-Alanine-
CAS No.	99571-73-0
Molecular Formula	C95H140N20O17
Molecular Weight	~1882.3 g/mol
Synonyms	Gramicidin A7A; [Ala7]-Gramicidin A; Gramicidin A (7-Alanine); Gramicidin A, 7-Ala-; HCO-L-Val-Gly-L-Ala-D-Leu-L-Ala-D-Val-L-Ala-D-Val-L-Trp-D-Leu-L-Trp-D-Leu-L-Trp-D-Leu-L-Trp-NHCH2CH2OH (with Trp7→Ala); 7-Alanine Gramicidin A; Gramicidin A Analog (Ala-7)
EINECS	Contact for details

Quality Control

Our Gramicidin A, 7-Alanine- is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for critical research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, MS for identity confirmation, and amino acid analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Amino Acid Analysis	Conforms to theoretical composition

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.