Description

Somatostatin, Des-Ala(1)-Des-Gly(2)-Trp(8)-Asn(3,14)- CAS NO 99312-73-9 is a synthetic analogue of the endogenous peptide hormone somatostatin, engineered for enhanced metabolic stability and receptor selectivity. This modified peptide is a critical research tool and a key intermediate in the development of targeted therapeutic agents, particularly for oncology and endocrinology. It is essential for pharmaceutical R&D, academic research, and biotech companies focused on neuroendocrine regulation, cancer therapy, and diagnostic imaging.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis of novel somatostatin receptor-targeting drugs for cancer and endocrine disorders.
• Preclinical Studies: Used in animal models to study the pharmacokinetics, biodistribution, and efficacy of somatostatin analogue-based therapies.
• Receptor Binding Assays: Employed as a reference standard or competitor in vitro to characterize the binding affinity and specificity of new compounds for somatostatin receptors (SSTRs).
• Radiopharmaceutical Precursor: Serves as a crucial building block for the chelator-conjugation and subsequent radiolabeling (e.g., with Gallium-68, Lutetium-177) to create targeted diagnostic and therapeutic radiopharmaceuticals.
• Biochemical Research: Investigation of somatostatin's role in inhibiting the secretion of hormones like growth hormone, insulin, and glucagon.
• Academia & Contract Research Organizations (CROs): Fundamental research into peptide chemistry, structure-activity relationships (SAR), and signal transduction pathways.

Basic Information

Product Name	Somatostatin, Des-Ala(1)-Des-Gly(2)-Trp(8)-Asn(3,14)- CAS NO 99312-73-9
CAS No.	99312-73-9
Molecular Formula	C72H104N18O19S2
Molecular Weight	1549.8 g/mol
Synonyms	Des-Ala1,Des-Gly2-[Trp8,Asn3,14]-Somatostatin; [Asn3,14,Trp8]-Somatostatin(1-14); Somatostatin (1-14), 1-de-L-alanine-2-deglycine-8-L-tryptophan-3,14-L-asparagine-; Des-AA1,2-[Trp8,Asn3,14]SRIF; Modified Somatostatin-14 analogue; SRIF analogue; SSTR ligand precursor
EINECS	Contact for details

Quality Control

Our Somatostatin analogue is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity, mass spectrometry for confirmation, and stringent controls for residual solvents and related substances. A Certificate of Analysis (COA) detailing all specifications and test results is provided to ensure traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95.0%
Assay (Peptide Content)	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.