Description

3-Cyclopentane-D-Alanine is a high-purity, non-proteinogenic D-amino acid derivative featuring a cyclopentane ring, offering unique stereochemical and structural properties for advanced synthesis. This compound is valued for its role as a critical chiral building block in pharmaceutical research and development, enabling the creation of novel bioactive molecules with enhanced metabolic stability. It is primarily utilized by research institutions and pharmaceutical companies engaged in peptide mimetic design, medicinal chemistry, and the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in metabolic disease and oncology research.
• Peptidomimetics Development: Used to introduce conformational constraints and improve the metabolic stability and bioavailability of peptide-based drug candidates.
• Medicinal Chemistry & SAR Studies: Serves as a versatile building block for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate enzyme mechanisms and inhibition.
• Asymmetric Synthesis: Acts as a chiral auxiliary or starting material in asymmetric catalytic reactions to construct complex molecular architectures.
• Ligand and Probe Synthesis: Utilized in the development of diagnostic agents, imaging probes, and targeted ligands for biological systems.

Basic Information

Item	Details
Product Name	3-Cyclopentane-D-Alanine
CAS No.	99295-81-5
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	(R)-2-Amino-3-cyclopentylpropanoic acid; D-3-Cyclopentylalanine; (R)-3-Cyclopentylalanine; D-Cyclopentylalanine; (2R)-2-Amino-3-cyclopentylpropanoic acid; D-2-Amino-3-cyclopentylpropionic acid; (R)-α-Amino-cyclopentanepropanoic acid; 99295-81-5
EINECS	Contact for details

Quality Control

Our 3-Cyclopentane-D-Alanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.