Description

Glucagon, Tyr(22)- is a synthetic peptide analog of the glucagon hormone, featuring a specific tyrosine modification at position 22. This modification is critical for research into receptor binding affinity, metabolic pathways, and the development of novel diagnostic or therapeutic agents. It is an essential biochemical tool for pharmaceutical R&D, academic research, and biotechnology applications focused on diabetes, metabolic disorders, and peptide-based drug discovery.

Application

• Pharmaceutical Research & Development: Used as a reference standard and active ingredient in the development of novel glucagon receptor agonists and antagonists.
• Metabolic Disorder Studies: A key reagent in in vitro and in vivo research models for studying glucose metabolism, insulin secretion, and liver function.
• Biochemical Assay Development: Serves as a critical component in the development and validation of immunoassays (ELISA, RIA) and receptor binding assays.
• Structure-Activity Relationship (SAR) Studies: The Tyr(22) modification makes it invaluable for investigating the impact of specific amino acid substitutions on peptide hormone activity and stability.
• Academic & Clinical Research: Employed in university and hospital laboratories for fundamental research into endocrinology and peptide hormone signaling.
• Biotechnology Production: Used in process development and quality control for the manufacturing of related peptide-based pharmaceuticals.

Basic Information

Product Name	Glucagon, Tyr(22)-
CAS No.	99206-01-6
Molecular Formula	C153H225N43O49S
Molecular Weight	3484.7 g/mol
Synonyms	Tyr22-Glucagon; [Tyr22]-Glucagon; Glucagon (Tyr22); Glucagon, 22-L-tyrosine-; H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH (Tyr22 variant); 99206-01-6; Glucagon Tyr22 analog
EINECS	Contact for details

Quality Control

Our Glucagon, Tyr(22)- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for related substances and residual solvents. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%
Peptide Content (UV)	≥ 80.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.