Description

Saruplase CAS NO 99149-95-8 is a high-purity, single-chain urokinase-type plasminogen activator (scu-PA) with significant thrombolytic activity. This recombinant protein is critical for research and development in cardiovascular therapeutics, specifically targeting arterial and venous thrombosis. It is primarily utilized by pharmaceutical R&D teams, biotechnology firms, and academic research institutions focused on developing next-generation clot-dissolving agents and studying fibrinolysis mechanisms.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of advanced thrombolytic drugs for the treatment of acute myocardial infarction, pulmonary embolism, and ischemic stroke.
• Biomedical Research: Essential tool for in vitro and in vivo studies of the fibrinolytic system, plasminogen activation pathways, and thrombosis models.
• Enzymology Studies: Used to investigate the kinetics and specificity of serine proteases within the coagulation and fibrinolysis cascade.
• Reference Standard: Serves as a calibrated standard in bioassays, potency tests, and quality control procedures for urokinase-type products.
• Drug Discovery & Screening: Employed in high-throughput screening (HTS) platforms to identify and evaluate novel inhibitors or enhancers of fibrinolysis.
• Diagnostic Development: Used in the development of diagnostic kits and assays for measuring plasminogen activator activity or related biomarkers in clinical samples.

Basic Information

Product Name	Saruplase
CAS No.	99149-95-8
Molecular Formula	C1350H2100N372O420S18 (Approx., for recombinant protein)
Molecular Weight	~47,000 Da (Single-chain form)
Synonyms	Prourokinase; Recombinant Prourokinase; Single-Chain Urokinase-Type Plasminogen Activator; scu-PA; r-scu-PA; Saruplase (INN); rPro-UK; BM 06.022; YM866
EINECS	Contact for details

Quality Control

Our Saruplase is manufactured under strict quality management systems. Each batch is subjected to a comprehensive battery of analytical tests including HPLC for purity and identity, specific activity determination via clot lysis assay, and rigorous checks for related proteins and impurities. Certificates of Analysis (COA) detailing purity, potency, endotoxin levels, and sterility (where applicable) are provided to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized (freeze-dried) material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -70°C to -80°C to prevent activity loss. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/Activity)	Conforms to reference standard
Purity (SDS-PAGE, reduced)	≥ 95%
Purity (RP-HPLC)	≥ 98.0%
Specific Activity	≥ 100,000 IU/mg
Single-Chain Content (HPLC)	≥ 90%
Protein Content (UV)	≥ 90% of stated mass
Endotoxin	< 10 EU/mg
Residual Moisture (KF)	< 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.