Description

Tandospirone Hcl CAS NO 99095-10-0 is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) belonging to the azapirone class of compounds. It is a selective 5-HT1A receptor partial agonist, making it a critical component in the research and development of anxiolytic and antidepressant medications. This compound is essential for pharmaceutical manufacturers, R&D laboratories, and academic institutions focused on neuropharmacology and central nervous system (CNS) drug development.

Application

• Pharmaceutical API Synthesis: Primary use as the active ingredient in the formulation of anxiolytic drugs.
• Neuropharmacology Research: A key reference standard and tool compound for studying 5-HT1A receptor function and signaling pathways.
• Preclinical & Clinical Development: Serves as a critical intermediate in the development and scale-up of new CNS-targeted therapeutics.
• Analytical Reference Standard: Used in quality control laboratories for method development, validation, and assay calibration (HPLC, LC-MS).
• Academic Research: Utilized in university and institutional studies investigating anxiety, depression, and serotonin receptor mechanisms.
• Generic Drug Manufacturing: Sourced for the production of generic versions of established anxiolytic medications containing tandospirone.

Basic Information

Item	Detail
Product Name	Tandospirone Hcl
CAS No.	99095-10-0
Molecular Formula	C21H29N5O2·HCl
Molecular Weight	427.95 g/mol
Synonyms	Tandospirone Hydrochloride; SM-3997; Metanopirone; Sediel; 3aa,4b,7b,7aa-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dione hydrochloride; 4-[4-(Pyrimidin-2-yl)piperazin-1-yl]butyl hexahydro-4,7-methano-2H-isoindole-2,5(3H)-dione hydrochloride
EINECS	Contact for details

Quality Control

Our Tandospirone Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, suitable for pharmaceutical R&D and API use. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.