Description

4'-Hydroxydiazepam is a key benzodiazepine metabolite and a significant pharmaceutical intermediate. Its primary value lies in its role as a reference standard for analytical research and as a precursor in the synthesis of active pharmaceutical ingredients (APIs). This compound is essential for pharmaceutical manufacturers, analytical laboratories, and research institutions focused on drug metabolism studies, quality control, and forensic analysis.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of diazepam and its metabolites in drug testing and bioanalytical studies.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial intermediate in the synthesis and development of benzodiazepine-class pharmaceuticals.
• Metabolite Research: Critical for in-vitro and in-vivo studies investigating the metabolic pathways, pharmacokinetics, and pharmacodynamics of diazepam.
• Forensic Toxicology: Employed as an analytical standard in forensic laboratories for the accurate detection of benzodiazepines in biological samples.
• Quality Control & Assurance: Utilized by pharmaceutical QC labs to validate analytical methods, such as HPLC and LC-MS, for purity and impurity profiling.
• Academic & Clinical Research: Supports fundamental research in neuropharmacology, medicinal chemistry, and clinical studies on sedative-hypnotic drugs.

Basic Information

Product Name	4'-Hydroxydiazepam
CAS No.	17311-35-2
Molecular Formula	C₁₆H₁₃ClN₂O₂
Molecular Weight	300.74 g/mol
Synonyms	Nordazepam 4'-Hydroxy Derivative; 7-Chloro-1,3-dihydro-1-methyl-5-(4-hydroxyphenyl)-2H-1,4-benzodiazepin-2-one; 4'-OH-Diazepam; 4'-Hydroxy Nordazepam; 4-Hydroxydiazepam; 4'-Hydroxy Medazepam Metabolite; Ro 05-3350; 1-Methyl-5-(4-hydroxyphenyl)-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin-2-one
EINECS	Contact for details

Quality Control

Our 4'-Hydroxydiazepam is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets high-purity standards suitable for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive compound from degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.