Description

n-Boc-2-Fluoroaniline is a high-purity, protected aniline derivative featuring a tert-butoxycarbonyl (Boc) group and a fluorine substituent on the aromatic ring. This compound serves as a critical pharmaceutical intermediate and building block in advanced organic synthesis, enabling the controlled introduction of the 2-fluoroaniline moiety into complex molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the research and production of novel fluorinated pesticides and herbicides.
• Peptide Chemistry: Serves as a protected amino component in the synthesis of modified peptides and peptidomimetics.
• Material Science Research: Employed in the development of fluorinated polymers, liquid crystals, and advanced organic materials.
• Cross-Coupling Reactions: Acts as a substrate in Buchwald-Hartwig amination and other palladium-catalyzed coupling reactions.
• Protecting Group Strategy: The Boc group allows for orthogonal protection/deprotection sequences in multi-step synthetic routes.

Basic Information

Product Name	n-Boc-2-Fluoroaniline
CAS No.	98968-72-0
Molecular Formula	C11H14FNO2
Molecular Weight	211.23 g/mol
Synonyms	2-Fluoro-N-(tert-butoxycarbonyl)aniline; tert-Butyl (2-fluorophenyl)carbamate; N-(tert-Butoxycarbonyl)-2-fluoroaniline; N-Boc-2-fluoroaniline; Boc-2-F-aniline; 1-[(2-Fluorophenyl)amino]-2-methyl-2-propanol, 2-methyl-2-propanyl ester; Carbamic acid, N-(2-fluorophenyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our n-Boc-2-Fluoroaniline is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up applications. We adhere to cGMP principles where applicable. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is moisture-sensitive; ensure containers are sealed tightly after use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	85 - 90 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.