Description

Enkephalinamide, Gly(2)-Psi-(Methyleneoxy)-Gly(3)-Leu(5)- CAS NO 98900-28-8 is a synthetic, modified peptide analog of the endogenous opioid peptide enkephalin, designed with a unique psi-(methyleneoxy) backbone modification between glycine residues. This engineered structure is critical for enhancing metabolic stability and receptor binding affinity, making it a valuable tool for advanced neuropharmacological research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on neuroscience, pain management, and the development of novel therapeutic agents targeting the opioid receptor system.

Application

• Neuroscience Research: A key biochemical tool for studying the structure-activity relationships (SAR) of opioid peptides and their interactions with delta (δ) and mu (μ) opioid receptors.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the design of new analgesics with improved stability and reduced side-effect profiles.
• Biochemical Assays: Used in competitive binding assays, receptor autoradiography, and functional studies to characterize opioid receptor subtypes and signaling pathways.
• Metabolic Stability Studies: The psi-(methyleneoxy) modification makes it a model compound for investigating peptide resistance to enzymatic degradation in vitro and in vivo.
• Academic & Institutional Research: Employed in university and government labs for fundamental research into neuropeptides, pain mechanisms, and central nervous system function.

Basic Information

Product Name	Enkephalinamide, Gly(2)-Psi-(Methyleneoxy)-Gly(3)-Leu(5)- CAS NO 98900-28-8
CAS No.	98900-28-8
Molecular Formula	C28H44N6O8
Molecular Weight	592.69 g/mol
Synonyms	H-Gly-psi[CH2O]-Gly-Leu-NH2; [Psi(CH2O)2,5]Leu-Enkephalinamide; Tyr-Gly-psi-(CH2O)-Gly-Phe-Leu-NH2; Modified Leu-Enkephalin amide; Gly-Gly psi-methyleneoxy Leu-Enkephalinamide; Opioid peptide analog 98900-28-8; Leu-Enkephalin, [Gly2-Gly3 psi-(methyleneoxy)]-, amide
EINECS	Contact for details

Quality Control

This high-purity research chemical is manufactured under strict quality control protocols. Each batch is characterized using advanced analytical techniques including HPLC, MS, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This compound is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay	≥ 98% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.