Description

Atrial Natriuretic Factor (5-28) is a bioactive peptide fragment derived from the N-terminal region of the atrial natriuretic peptide (ANP) prohormone. This specific sequence is critical for research into cardiovascular physiology, renal function, and natriuretic peptide receptor interactions. It serves as an essential reference standard and active pharmaceutical ingredient (API) intermediate for pharmaceutical development and advanced life science research. Key industrial users include biopharmaceutical companies, contract research organizations (CROs), and academic institutions focused on cardiometabolic drug discovery and diagnostic assay development.

Application

• Pharmaceutical Reference Standard: Used for the calibration and validation of analytical methods (HPLC, MS) in quality control laboratories.
• Biomedical Research Reagent: Employed in in vitro and in vivo studies to investigate the structure-activity relationship (SAR) of natriuretic peptides.
• API Intermediate: Serves as a key building block in the synthetic production of novel ANP analogs and related therapeutic peptides.
• Diagnostic Development: Utilized in the development and manufacturing of immunoassays and ELISA kits for detecting ANP and related biomarkers.
• Signal Transduction Studies: Applied in cellular assays to study the activation of natriuretic peptide receptors (NPR-A, NPR-B) and downstream second messenger pathways.
• Cardiovascular & Renal Research: A fundamental tool for exploring mechanisms of blood pressure regulation, sodium homeostasis, and diuresis.

Basic Information

Product Name	Atrial Natriuretic Factor (5-28)
CAS No.	98897-20-2
Molecular Formula	C119H190N36O39S2
Molecular Weight	2741.1 g/mol
Synonyms	ANF (5-28); Atrial Natriuretic Peptide (5-28); ANP (5-28); Cardionatrin (5-28); Atriopeptin (5-28); hANP (5-28); Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr (Disulfide bridge: Cys7-Cys23)
EINECS	Contact for details

Quality Control

Our Atrial Natriuretic Factor (5-28) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by mass spectrometry (MS) and purity assessment by reverse-phase high-performance liquid chromatography (RP-HPLC). We provide full traceability and Certificates of Analysis (COA) detailing purity, peptide content, and related substances. Our quality commitment ensures material suitable for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%
Bacterial Endotoxins	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.