Description

2-Ala-4-(4-Azido-Phe)-Met-Enkephalin is a synthetic, azide-functionalized derivative of the endogenous opioid peptide [Met]-enkephalin. This compound is specifically engineered as a photoaffinity labeling probe for biochemical research, enabling the covalent cross-linking and identification of opioid receptor binding sites. It is an essential tool for neuroscience researchers, pharmacologists, and medicinal chemists engaged in the study of opioid receptor structure, function, and ligand interactions.

Application

• Photoaffinity Labeling Studies: Primary application for covalent tagging and mapping of opioid receptor (e.g., μ, δ) binding domains.
• Receptor Biochemistry: Used to isolate and characterize opioid receptor proteins from tissue homogenates or cell membranes.
• Medicinal Chemistry & Drug Discovery: Serves as a molecular probe in the design and development of novel analgesic compounds.
• Neuroscience Research: Investigation of the endogenous enkephalinergic system, signal transduction pathways, and receptor dynamics.
• Bioconjugation & Probe Development: The azido group allows for further functionalization via click chemistry for creating advanced diagnostic or therapeutic agents.

Basic Information

Product Name	2-Ala-4-(4-Azido-Phe)-Met-Enkephalin
CAS No.	98749-66-7
Molecular Formula	C32H42N8O7S
Molecular Weight	682.80 g/mol
Synonyms	[D-Ala2, 4-Azido-Phe4]-Met-Enkephalin; Tyr-D-Ala-Gly-(4-Azido-Phe)-Met-OH; 4-Azido-Phenylalanine4-Met-Enkephalin; D-Ala2, N3-Phe4-Met-Enkephalin; Photoactivatable Met-Enkephalin; Opioid Receptor Photoaffinity Probe; Azido-Enkephalin; p-Azido-Phe4-Met-Enkephalin
EINECS	Contact for details

Quality Control

Our 2-Ala-4-(4-Azido-Phe)-Met-Enkephalin is produced under strict quality protocols suitable for research applications. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and stability. Certificates of Analysis (COA) detailing HPLC purity, MS confirmation, and other relevant tests are provided to support your research integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic and light-sensitive nature, allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.