Description

5-Ethynyl-1-(3-Hydroxy-4-(Hydroxymethyl)Cyclopentyl)-2,4(1H,3H)-Pyrimidinedione is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This compound is valued for its role as a key synthetic building block in the development of novel antiviral and anticancer therapeutics. It is primarily sought by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions engaged in nucleoside analog and prodrug synthesis.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel nucleoside analog drugs targeting viral infections.
• Antiviral Drug Research: Used in the R&D of prodrugs and active pharmaceutical ingredients (APIs) for hepatitis and other viral diseases.
• Oncology Research: Serves as a precursor in the development of chemotherapeutic agents and targeted cancer therapies.
• Biochemical Research: Utilized in enzymatic studies and as a substrate or inhibitor in biochemical assays.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial manufacturing of specialty active compounds.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	5-Ethynyl-1-(3-Hydroxy-4-(Hydroxymethyl)Cyclopentyl)-2,4(1H,3H)-Pyrimidinedione
CAS No.	98736-95-9
Molecular Formula	C12H12N2O4
Molecular Weight	248.24 g/mol
Synonyms	5-Ethynyl-1-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)pyrimidine-2,4(1H,3H)-dione; 5-Ethynyl-1-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)uracil; 5-Ethynyl-1-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)-2,4-dihydroxypyrimidine; 5-Ethynyl-1-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)-2,4-pyrimidinedione; 5-Ethynyl-1-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)-2,4(1H,3H)-pyrimidinedione; 5-Ethynyl-1-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine; 5-Ethynyl-1-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)uracil; 5-Ethynyl-1-(3-hydroxy-4-(hydroxymethyl)cyclopentyl)-2,4(1H,3H)-pyrimidinedione
EINECS	Contact for details

Quality Control

Our 5-Ethynyl-1-(3-Hydroxy-4-(Hydroxymethyl)Cyclopentyl)-2,4(1H,3H)-Pyrimidinedione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP, ICH Q7, and other relevant pharmaceutical guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.