Description

Angiotensin II, Sar(1)-Phe(4)- is a potent, synthetic peptide analog of the endogenous vasoconstrictor hormone Angiotensin II, specifically modified to enhance receptor binding affinity and metabolic stability. This compound is a critical research tool for studying the renin-angiotensin system (RAS), which is central to cardiovascular physiology, blood pressure regulation, and renal function. It is essential for pharmaceutical R&D, academic research, and diagnostic development in cardiology, nephrology, and endocrinology.

Application

• Pharmacological Research: Used as a selective AT1 receptor agonist to study receptor signaling pathways, vascular smooth muscle contraction, and aldosterone secretion in in vitro and ex vivo models.
• Cardiovascular Disease Modeling: A key agent for inducing hypertension and studying the pathophysiology of heart failure, atherosclerosis, and cardiac remodeling in preclinical animal studies.
• Drug Discovery & Screening: Serves as a reference standard and target ligand in high-throughput screening (HTS) assays to identify and characterize novel angiotensin receptor blockers (ARBs) or modulators.
• Biochemical Assay Development: Employed in the development and validation of competitive binding assays (e.g., radioimmunoassays, ELISA) to quantify angiotensin peptides or receptor activity.
• Academic & Educational Use: A fundamental reagent for teaching and investigating hormone action, G-protein coupled receptor (GPCR) mechanisms, and peptide chemistry in university laboratories.
• Diagnostic Kit Manufacturing: May be utilized as a calibrated standard or component in diagnostic kits for measuring components of the renin-angiotensin system in clinical samples.

Basic Information

Product Name	Angiotensin II, Sar(1)-Phe(4)-
CAS No.	98641-02-2
Molecular Formula	C49H69N13O11
Molecular Weight	1032.2 g/mol
Synonyms	[Sar1,Phe4]-Angiotensin II; Saralasin Acetate; 1-Sarcosine-4-phenylalanine angiotensin II; Sar1,Phe8-Ang II; (Sar1,Phe8)-Angiotensin II; Angiotensin II antagonist; Sarmesin; NSC-401834
EINECS	Contact for details

Quality Control

Our Angiotensin II, Sar(1)-Phe(4)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with each shipment, documenting purity, peptide content, and solvent residues. Production can adhere to cGMP guidelines for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by AAA)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.