Description

Angiotensin II, Sar(1)-Phe(4)-Ile(8)- is a potent synthetic peptide analog of the endogenous vasoconstrictor hormone Angiotensin II, specifically designed with amino acid substitutions to enhance receptor affinity and metabolic stability. This compound is critical for advanced biochemical research and pharmaceutical development, particularly in the study of the renin-angiotensin system (RAS) and cardiovascular physiology. It serves as an essential tool for researchers and developers in pharmacology, biotechnology, and diagnostic assay production, where precise receptor-ligand interactions are paramount.

Application

• Biomedical Research: Used as a high-affinity ligand in receptor binding assays and signal transduction studies related to the AT1 and AT2 receptors.
• Pharmaceutical R&D: Serves as a reference standard and a key intermediate in the development of novel cardiovascular drugs and antihypertensive agents.
• Diagnostic Development: Employed in the calibration and validation of immunoassays and test kits designed to measure components of the renin-angiotensin system.
• Academic Studies: Facilitates fundamental research into blood pressure regulation, vascular smooth muscle contraction, and aldosterone secretion mechanisms.
• Peptide Chemistry: Acts as a model compound for studying structure-activity relationships (SAR) and peptide modification techniques.

Basic Information

Product Name	Angiotensin II, Sar(1)-Phe(4)-Ile(8)-
CAS No.	98641-01-1
Molecular Formula	C49H69N13O10
Molecular Weight	1000.2 g/mol
Synonyms	[Sar1,Phe4,Ile8]-Angiotensin II; Saralasin Acetate; 1-Sarcosine-4-phenylalanine-8-isoleucine Angiotensin II; Saralasin; Sarenin; P-113; NSC-329853; (Sar1, Ile8)-Angiotensin II
EINECS	Contact for details

Quality Control

Our Angiotensin II, Sar(1)-Phe(4)-Ile(8)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.