Description

D-n-Cbz-3-Pyrazol-1-Yl-Alanine is a specialized, non-proteinogenic amino acid derivative featuring a pyrazole-protected side chain. This compound is a crucial chiral building block in modern pharmaceutical research and development, enabling the synthesis of complex molecules with high stereochemical fidelity. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology sectors for the creation of novel therapeutic agents, including protease inhibitors and other bioactive peptides.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly in the field of protease inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate a unique, protected pyrazole-functionalized alanine residue into peptide chains.
• Medicinal Chemistry: Serves as a building block for structure-activity relationship (SAR) studies and for creating libraries of compounds with potential biological activity.
• Bioconjugation: The reactive functional groups make it suitable for creating peptide-based conjugates for targeted drug delivery or diagnostic applications.
• Chemical Biology Probes: Used in the development of chemical probes to study enzyme function and protein-protein interactions.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	D-n-Cbz-3-Pyrazol-1-Yl-Alanine
CAS No.	98632-92-9
Molecular Formula	C14H15N3O4
Molecular Weight	289.29 g/mol
Synonyms	D-3-(N-Carbobenzyloxy-1H-pyrazol-1-yl)alanine; (R)-2-(((Benzyloxy)carbonyl)amino)-3-(1H-pyrazol-1-yl)propanoic acid; D-Cbz-3-(1-Pyrazolyl)alanine; N-Carbobenzyloxy-D-3-pyrazolylalanine; D-N-Cbz-3-(1-Pyrazolyl)alanine; (R)-2-((((Benzyloxy)carbonyl)amino)-3-(1H-pyrazol-1-yl)propanoic acid; D-1-Cbz-3-pyrazol-1-yl-alanine
EINECS	Contact for details

Quality Control

Our D-n-Cbz-3-Pyrazol-1-Yl-Alanine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.