Description

Pro-Thyrotropin Releasing Hormone (Pro-TRH) is a synthetic peptide analog of the endogenous thyrotropin-releasing hormone, a critical hypothalamic regulatory hormone. This high-purity compound is essential for advanced research and development in neuroendocrinology and diagnostic applications. It is primarily utilized by pharmaceutical R&D teams, clinical diagnostics manufacturers, and academic research institutions studying the hypothalamic-pituitary-thyroid axis.

Application

• Pharmaceutical Reference Standard: Serves as a critical calibrant and quality control standard in the development and validation of TRH-based therapeutics and diagnostic assays.
• Biochemical Research: Used as a key reagent in studies investigating the synthesis, processing, and physiological role of thyrotropin-releasing hormone and its precursors.
• Diagnostic Kit Manufacturing: Incorporated as a core component in immunoassay kits for the quantitative measurement of TRH and related peptides in clinical samples.
• Neuroscience & Endocrinology Studies: Applied in vitro and in vivo research to explore central nervous system functions, pituitary hormone regulation, and metabolic pathways.
• Peptide Chemistry Development: Acts as a model compound for developing novel peptide synthesis, purification, and analytical methodologies.

Basic Information

Product Name	Pro-Thyrotropin Releasing Hormone
CAS No.	98616-54-7
Molecular Formula	C16H22N6O4
Molecular Weight	362.38 g/mol
Synonyms	Prepro-Thyrotropin-Releasing Hormone (160-169); TRH-Gly; pGlu-His-Pro-Gly; L-Pyroglutamyl-L-histidyl-L-prolylglycine; Pro-TRH; Thyroliberin Precursor Fragment; Prepro-TRH (160-169); pGlu-His-Pro-Gly-OH
EINECS	Contact for details

Quality Control

Our Pro-Thyrotropin Releasing Hormone is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and stringent tests for residual solvents and related substances. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.